SidaGhanaV1, Main, Exploration, bibRecord, 000793

Diagnosis of treponemal co-infection in HIV-infected West Africans

Identifieur interne : 000793 ( Main/Exploration ); précédent : 000792; suivant : 000794

Diagnosis of treponemal co-infection in HIV-infected West Africans

Auteurs : Yaasir Mamoojee [Royaume-Uni] ; Grace Tan [Royaume-Uni] ; Sandra Gittins [Royaume-Uni] ; Stephen Sarfo [Ghana] ; Lisa Stephenson [Royaume-Uni] ; David Carrington [Royaume-Uni] ; George Bedu-Addo [Ghana] ; Richard Phillips [Ghana] ; Lambert T. Appiah [Ghana] ; David Chadwick [Royaume-Uni]

Source :

TM & IH. Tropical medicine & international health [ 1360-2276 ] ; 2012.

RBID : Pascal:13-0002896

Descripteurs français

Pascal (Inist)
- Tréponématose, Infection mixte, SIDA, Diagnostic, Syphilis, Pian, Virus immunodéficience humaine, Afrique, Evaluation performance, Médecine tropicale.

English descriptors

KwdEn :
- AIDS, Africa, Diagnosis, Human immunodeficiency virus, Mixed infection, Performance evaluation, Syphilis, Treponematosis, Tropical medicine, Yaws.

Abstract

OBJECTIVES To evaluate the performance of two enzyme immunoassays (EIA), Murex and ICE, and the Determine TP point-of-care test (POCT) in diagnosing treponemal infection (syphilis or yaws) in patients attending a large HIV clinic in Ghana; to determine the prevalence of treponemal co-infections; and to characterise demographic and clinical features of patients with infection. METHODS Samples were tested with EIAs and rapid plasma reagin (RPR), then POCT and reference assays for Treponema pallidum to determine prevalence of active and past infection. Sensitivity and specificity of each assay were calculated and demographic and clinical characteristics of patients compared. Data were collected from case notes of patients retrospectively. RESULTS Overall, 45/284 patient samples (14.8%, 95% CI, 11.1-19.4%) were Treponema pallidum particle agglutination (TPPA) positive, and of these, 27 (64.3%) were RPR positive and 4 (8.9%) were treponemal IgM positive. Both EIAs and Determine TP POCT showed high sensitivities and specificities for identifying infection although RPR was less reliable. Clinical features of syphilis or yaws were rarely identified in TPPA-positive patients suggesting most had previous or late latent infection. Treatment of various intercurrent infections using short courses of antibiotics active against T. pallidum was common in the clinic. CONCLUSIONS A high proportion of this HIV-infected cohort showed evidence of treponemal infection. Both EIAs as well as the POCT were practical and effective at diagnosing treponemal co-infection in this setting. RPR alone was unreliable at identifying active treponemal co-infection, however might be useful in some settings where treponemal-specific assays are unaffordable.

Affiliations:

Ghana, Royaume-Uni

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to stream PascalFrancis, to step Checkpoint: 000019
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to stream Main, to step Curation: 000793

Le document en format XML

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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>AIDS</term>
<term>Africa</term>
<term>Diagnosis</term>
<term>Human immunodeficiency virus</term>
<term>Mixed infection</term>
<term>Performance evaluation</term>
<term>Syphilis</term>
<term>Treponematosis</term>
<term>Tropical medicine</term>
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<keywords scheme="Pascal" xml:lang="fr"><term>Tréponématose</term>
<term>Infection mixte</term>
<term>SIDA</term>
<term>Diagnostic</term>
<term>Syphilis</term>
<term>Pian</term>
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<term>Afrique</term>
<term>Evaluation performance</term>
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<front><div type="abstract" xml:lang="en">OBJECTIVES To evaluate the performance of two enzyme immunoassays (EIA), Murex and ICE, and the Determine TP point-of-care test (POCT) in diagnosing treponemal infection (syphilis or yaws) in patients attending a large HIV clinic in Ghana; to determine the prevalence of treponemal co-infections; and to characterise demographic and clinical features of patients with infection. METHODS Samples were tested with EIAs and rapid plasma reagin (RPR), then POCT and reference assays for Treponema pallidum to determine prevalence of active and past infection. Sensitivity and specificity of each assay were calculated and demographic and clinical characteristics of patients compared. Data were collected from case notes of patients retrospectively. RESULTS Overall, 45/284 patient samples (14.8%, 95% CI, 11.1-19.4%) were Treponema pallidum particle agglutination (TPPA) positive, and of these, 27 (64.3%) were RPR positive and 4 (8.9%) were treponemal IgM positive. Both EIAs and Determine TP POCT showed high sensitivities and specificities for identifying infection although RPR was less reliable. Clinical features of syphilis or yaws were rarely identified in TPPA-positive patients suggesting most had previous or late latent infection. Treatment of various intercurrent infections using short courses of antibiotics active against T. pallidum was common in the clinic. CONCLUSIONS A high proportion of this HIV-infected cohort showed evidence of treponemal infection. Both EIAs as well as the POCT were practical and effective at diagnosing treponemal co-infection in this setting. RPR alone was unreliable at identifying active treponemal co-infection, however might be useful in some settings where treponemal-specific assays are unaffordable.</div>
</front>
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<li>Royaume-Uni</li>
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<tree><country name="Royaume-Uni"><noRegion><name sortKey="Mamoojee, Yaasir" sort="Mamoojee, Yaasir" uniqKey="Mamoojee Y" first="Yaasir" last="Mamoojee">Yaasir Mamoojee</name>
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<name sortKey="Carrington, David" sort="Carrington, David" uniqKey="Carrington D" first="David" last="Carrington">David Carrington</name>
<name sortKey="Chadwick, David" sort="Chadwick, David" uniqKey="Chadwick D" first="David" last="Chadwick">David Chadwick</name>
<name sortKey="Gittins, Sandra" sort="Gittins, Sandra" uniqKey="Gittins S" first="Sandra" last="Gittins">Sandra Gittins</name>
<name sortKey="Stephenson, Lisa" sort="Stephenson, Lisa" uniqKey="Stephenson L" first="Lisa" last="Stephenson">Lisa Stephenson</name>
<name sortKey="Tan, Grace" sort="Tan, Grace" uniqKey="Tan G" first="Grace" last="Tan">Grace Tan</name>
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<name sortKey="Appiah, Lambert T" sort="Appiah, Lambert T" uniqKey="Appiah L" first="Lambert T." last="Appiah">Lambert T. Appiah</name>
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Le SIDA au Ghana (serveur d'exploration)

Diagnosis of treponemal co-infection in HIV-infected West Africans

Diagnosis of treponemal co-infection in HIV-infected West Africans

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri